Skip to main content

Off the Bench Podcast: Acute Myeloid Leukemia Workup, Management, And Prognosis With Dr. John McClure


A low predisposition risk patient in his 20s arrives at urgent care with fever and fatigue. Diagnosis? Acute Myeloid Leukemia (AML). In this podcast, we speak with Dr. John McClure about general case management of patients with AML. Dr. McClure walks us through the lab testing necessary to identify AML, the best- and worst-case scenarios for patient outcomes, and where a medical technologist fits into the process.


Upon completion of this self-study course, participants will be able to:
  • Differentiate between the peripheral blood hematology findings in acute versus chronic leukemia.
  • List predisposing factors for patients with Acute Myeloid Leukemia.
  • Correlate how molecular and cytogenetic abnormalities contribute to the prognosis and response to treatment in patients with AML.
  • List indications for a bone marrow transplant.


This self-study is P.A.C.E. ® accredited. The instruction level for this activity is Intermediate. One (1) P.A.C.E. ® contact hours and one (1) Florida credit hours in the area General (Hematology) will be awarded to participants. ASCLS P.A.C.E.® is accepted by the ASCP/ASCLS/AGT Board of Certification and all states, including Florida and California, as an approved provider of continuing education for recertification and licensure. ASCLS is an approved provider with CE Broker for Florida licensees.


Dr. John S. McClure is a pathologist in Minneapolis, Minnesota, and is affiliated with multiple hospitals in the area. He has been in practice for more than 20 years and his prior accomplishments include being a course director at the University of Minnesota in Lab Medicine and Pathology and a medical director at various hospital and clinical laboratories around the Twin Cities Area. He’s always wanted to be a professional brewer or bagpipe player but couldn’t cut it in either field so he settled for hematopathology.

This intermediate-level program is appropriate for laboratory professionals working in clinical, public health and academic settings.

Dunford, A. et. Al. Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias. Nature Genetics. 2017. 49(1): 10-16.

Soos, M.P., et. Al. Blue-green neutrophilic inclusion bodies in the critically ill patient. Clinical Case Reports. 2019. 7: 1249-1252.