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Biotin Interference in Clinical Immunoassays: An Overview

From the 2020 Joint Annual Meeting (July 1, 2020)
Presented by Minh Kosfeld, PhD, MLT(ASCP)CM
Biotin is a B vitamin that is a cofactor in a variety of metabolic reactions. It is a component of the capture antibody complex in some immunoassays, and intake of Biotin megadoses can interfere with these assays. This presentation addresses the mechanism of interference and ways to mitigate the effect.

LEARNING OBJECTIVES
At the conclusion of this presentation, participants will be able to:

  1. Explain the mechanism of biotin interference in the commonly used diagnostic immunoassays.
  2. Identify common laboratory tests affected by biotin interference and provide examples of its impact on clinical diagnoses.
  3. Summarize current approaches to identify and minimize the effects of biotin interference.

CE ACCREDITATION
This recorded presentation is P.A.C.E. ® accredited. The instruction level for this activity is Intermediate. One (1) P.A.C.E. ® contact hour and one (1) Florida credit hour in the area of Chemistry/Immunology will be awarded to participants. ASCLS P.A.C.E.® is accepted by the ASCP/ASCLS/AGT Board of Certification and all states, including Florida and California, as an approved provider of continuing education for recertification and licensure. ASCLS is an approved provider with CE Broker for Florida licensees.

LEVEL OF INSTRUCTION
This intermediate-level program is appropriate for laboratory professionals working in clinical, public health and academic settings.